ChemInform Abstract: Morita—Baylis—Hillman Route to 4H-Pyrrolo[1,2-a][1]benzazepine Derivatives.
✍ Scribed by Sun Pil Park; Young Seok Song; Kee-Jung Lee
- Publisher
- John Wiley and Sons
- Year
- 2009
- Weight
- 32 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Key feature of the synthesis of title pyrrolopyrazine scaffolds is the Curtius reaction of formylpyrrolyl‐substituted acids to generate an isocyanate, which is directly cyclized in the presence of formic acid [cf.
## Abstract magnified image A new, simple synthesis of 5‐carbomethoxy‐4__H__‐1,2,3‐triazolo[1,5‐__a__][1]benzazepines from the reaction of several Baylis‐Hillman acetates of 2‐azidobenzaldehydes with alkynide Grignard reagents such as phenylethynyl‐, 1‐propynyl‐ and ethynylmagnesium bromides follo
## Abstract Novel heterocycles, 4__H__‐tetrazolo[1,5‐__a__][1]benzazepines **6** were prepared by the intramolecular 1,3‐dipolar cycloaddition reaction of azidophenylcyanomethyl compounds **5.** The latter were readily obtained from 2‐azidobenzaldehyde through the Baylis‐Hillman adducts **3** follo