ChemInform Abstract: Mechanism of the Formation of 1,2,4-Thiadiazoles by Condensation of Aromatic Thioamides and of N-Substituted Thioureas.
β Scribed by Luciano Forlani; Andrea Lugli; Carla Boga; Anna Bonamartini Corradi; Paolo Sgarabotto
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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Synthesis and Cyclization of 1-(N-Nitroamidino)thioureas to 2,4-Diaminothiazoles. -Reaction of nitroguanidine (I) with isothiocyanates in the presence of powdered KOH provides 1-(N-nitroamidino)thioureas (III) which react with phenacyl bromides to give unexpectedly 2,4-diaminothiazoles (V) in high
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