## Abstract ## BACKGROUND. In previous studies, alemtuzumab demonstrated considerable activity in patients with previously treated Bβcell chronic lymphocytic leukemia (CLL), including fludarabineβrefractory disease. In this retrospective study, the authors evaluated the benefit of alemtuzumab mono
ChemInform Abstract: Management Guidelines for the Use of Alemtuzumab in Chronic Lymphocytic Leukemia
β Scribed by A. Oesterborg; R. Foa; R. F. Bezares; C. Dearden; M. J. S. Dyer; C. Geisler; T. S. Lin; M. Montillo; M. H. J. van Oers; C.-M. Wendtner; et al. et al.
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 15 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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For many years it has been evident that B-cell chronic lymphocytic leukemia (CLL) displays preferential usage of individual immunoglobulin (Ig) variable heavy chain (V(H)) genes. The V(H)1-69 gene was the first to be reported overrepresented in a large number of CLL patients, where the V(H)1-69(+) C
## Abstract Over a 24βyear period, 137 patients were referred for management of newly diagnosed chronic lymphocytic leukemia. One hundred and nineteen patients have been reviewed in terms of response to therapy and prognostic factors for survival; 18 patients were excluded either because lymph node