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ChemInform Abstract: Lipoxygenase Inhibitor. Part 6. Synthesis of New Tetrahydropyrazine and Other Heterocyclic Compounds by Reaction of Hydrazonoyl Chlorides.

✍ Scribed by P. FROHBERG; M. WIESE; P. NUHN

Book ID: 101850999
Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199733051

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✦ Synopsis

Synthesis of New Tetrahydropyrazine and Other Heterocyclic Compounds by Reaction of Hydrazonoyl

Chlorides.

-New cyclization reactions with hydrazonoyl chlorides (II), (V), (X) are described. Only dimerization of (X) occurs in the presence of N,N'-diphenyl thiourea. The formed arylhydrazone products (III), (VI), (VIII) are more potent 5-lipoxygenase inhibitors than thiazole (XI). -(FROHBERG,

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