ChemInform Abstract: Lipase-Mediated Synthesis of the Enantiomeric Forms of 4,5-Epoxy-4,5-dihydro-α-ionone and 5,6-Epoxy-5,6-dihydro-β-ionone. A New Direct Access to Enantiopure (R)- and (S)-α-Ionone.

✍ Scribed by Josefina Aleu; Elisabetta Brenna; Claudio Fuganti; Stefano Serra

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199924187

✦ Synopsis

Lipase-Mediated Synthesis of the Enantiomeric Forms of 4,5-Epoxy-4,5-dihydro-α-ionone and 5,6-Epoxy-5,6-dihydro-β-ionone. A New Direct Access to Enantiopure (R)-and (S)-α-Ionone.

-In continuation of a recent study a lipase-mediated approach to optically active α-ionone starting from its racemate is developed. The enantiomer of (R)-(I) is obtained in an identical fashion starting with the racemate of (II) instead of (III). A similar way is used for the synthesis of the (+)-enantiomer of the 5,6-epoxide from β-ionone.