✦ LIBER ✦
ChemInform Abstract: Lipase-Catalyzed Chemoselective N-Acylation of Amino-Sugar Derivatives in Hydrophobic Solvent: Acid-Amine Ion-Pair Effects.
✍ Scribed by T. MAUGARD; M. REMAUD-SIMEON; D. PETRE; P. MONSAN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Lipase-Catalyzed Chemoselective N-Acylation of Amino-Sugar Derivatives in Hydrophobic Solvent: Acid-Amine Ion-Pair Effects.
-The enzymatic chemoselective acylation of N-methyl-glucamine (I) in hexane without the use of protecting groups leads to amides, which are of interest as biodegradable nonionic surfactants. The chemoselectivity and the yield of the reaction are controlled by the molar acid/amine ratio.