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ChemInform Abstract: Large-Scale Synthesis of New Pyranoid Building Blocks Based on Aldolase-Catalyzed Carbon—Carbon Bond Formation.

✍ Scribed by Michael Wolberg; Ben H. N. Dassen; Martin Schuermann; Stefan Jennewein; Marcel G. Wubbolts; Hans E. Schoemaker; Daniel Mink

Publisher
John Wiley and Sons
Year
2008
Weight
55 KB
Volume
39
Category
Article
ISSN
0931-7597

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Large-Scale Synthesis of New Pyranoid Bu
Large-Scale Synthesis of New Pyranoid Building Blocks Based on Aldolase-Catalysed Carbon-Carbon Bond Formation
✍ Michael Wolberg; Ben H. N. Dassen; Martin Schürmann; Stefan Jennewein; Marcel G. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB

## Abstract A new large‐scale approach to the synthetically versatile chloromethyl‐substituted, α,β‐unsaturated δ‐lactone **3** is described. The synthesis is based on a biocatalytic process performed on an industrial scale. Conjugate addition of __C__‐, __N__‐, __O__‐, and __S__‐nucleophiles to la