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ChemInform Abstract: Lactacystin, a Proteasome Inhibitor: Discovery and Its Application in Cell Biology

โœ Scribed by Hiroshi Tomoda; Satoshi Omura

Publisher
John Wiley and Sons
Year
2001
Weight
25 KB
Volume
32
Category
Article
ISSN
0931-7597

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The multicatalytic protease complex or proteasome is a fundamental nonlysosomal tool that the cell uses to process or degrade proteins at a fast rate through the ubiquitin and ATP-dependent proteolytic pathway. Examples of these important proteins include the tumor suppressor protein p53, various cy