ChemInform Abstract: L-(+)-Swainsonine and Other Pyrrolidine Inhibitors of Naringinase: Through an Enzymic Looking Glass from D-Mannosidase to L-Rhamnosidase?

✍ Scribed by B. DAVIS; A. A. BELL; R. J. NASH; A. A. WATSON; R. C. GRIFFITHS; M. G. JONES; C. SMITH; G. W. J. FLEET

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199712205

✦ Synopsis

1997 carbohydrates carbohydrates U 0500 12 -205 L-(+)-Swainsonine and Other Pyrrolidine Inhibitors of Naringinase: Through an Enzymic Looking Glass from D-Mannosidase to L-Rhamnosidase? -Compounds such as (I)-(VI) are synthesized and their title inhibitory activities together with those of other known derivatives are evaluated. In this series of L-swainsonine (IV) with an IC50 of 0.3 . mu.M is the most active inhibitor of naringinase. -(DAVIS, B.;