ChemInform Abstract: Isocyanide-Based Three-Component Synthesis of Functionalized 5-Alkylimino-2,5-dihydrofuran-3,4-dicarboxylate (IV) and Their Conversion to Substituted Furanones (V).

Isocyanide-based three-component synthes

Isocyanide-based three-component synthesis of functionalized 5-alkylimino-2,5-dihydrofuran-3,4-dicarboxylate and their conversion to substituted furanones

✍ Zinatossadat Hossaini; Hosein Hamadi; Faramarz Rostami Charati; Mehdi Khoobi; Ab 📂 Article 📅 2011 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 145 KB

## Abstract The zwitterionic 1:1 intermediates formed from alkyl isocyanides and acetylenic esters are trapped by alkyl bromides to form 5‐alkylimino‐2,5‐dihydrofuran‐3,4‐dicarboxylate in relatively good yields at room temperature under solventless conditions. Hydrolysis of these compounds by HCl (