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ChemInform Abstract: Iodine Catalyzed One-Pot Five-Component Reactions for Direct Synthesis of Densely Functionalized Piperidines.

✍ Scribed by Abu T. Khan; Md. Musawwer Khan; Kranthi K. R. Bannuru

Publisher: John Wiley and Sons
Year: 2011
Weight: 62 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201105142

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✦ Synopsis

Abstract

The reaction of 1,3‐dicarbonyl compounds (I) or (V) with 2 molecules of an aromatic or aliphatic amine and two molecules of a benzaldehyde affords the piperidines.

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## Abstract The process allows the synthesis of moderate to good yields of the target compounds, required as synthons for natural products and bioactive substances.The method fails if α‐naphthylamine is used.