✦ LIBER ✦
ChemInform Abstract: Inverse Agonists at the Polyamine-Sensitive Modulatory Site of the NMDA Receptor: 50-Fold Increase in Potency by Insertion of an Aromatic Ring into an Alkanediamine Chain.
✍ Scribed by M. L. BERGER; C. SCHOEDL; C. R. NOE
- Book ID
- 101868814
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Inverse Agonists at the Polyamine-Sensitive Modulatory Site of the NMDA Receptor: 50-Fold Increase in Potency by Insertion of an Aromatic Ring into an Alkanediamine Chain. -Among the products synthesized derivative (Ic) represents the most potent polyamine inverse agonist presently known. It inhibits the specific binding of [ 3 H]MK-801 with an IC 50