ChemInform Abstract: Intramolecular Cycloaddition of Azomethine Ylides in the Preparation of Pyrrolidino[2′,3′:3,4]pyrrolidino[1,2-a]benzimidazoles.
✍ Scribed by Liping Meng; James C. Fettinger; Mark J. Kurth
- Publisher
- John Wiley and Sons
- Year
- 2008
- Weight
- 40 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## 23 -130 [2 + 3] Cycloadditions of Azomethine Ylides with 1,3-Thiazole-5(4H)thiones. -Azomethine ylides, generated thermally from trans and cis aziridines (I), (VII), (VIII), and (X) give with thiazolethiones (II) in almost all cases mixtures of only two diastereomeric spirocyclic [2 + 3] cycloa
## Abstract The reaction of the compounds (I) with the compound (II) by heating in toluene gives the product (III) in similar yields but in longer reaction times (25‐30 h).