Enzymatic semisynthesis of human insulin
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Kazuyuki Morihara
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Article
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1990
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John Wiley and Sons
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English
โ 482 KB
## Abstract Peptide bond formation can be enzymatically catalysed by the reverse reaction of proteases. Application is seen in the industrial production of human insulin. Human insulin derivative can be enzymatically prepared using either porcine insulin or the single chain B(1โ29)โA(1โ21) insulin