ChemInform Abstract: Influence of Quaternization or Coordination of Nitrogen with a Lewis Acid upon the Diastereoselectivity of 5-exo Ring Closure of β-Aminoalkyl Radicals.

Influence of quaternization or coordinat

Influence of quaternization or coordination of nitrogen with a Lewis acid upon the diastereoselectivity of 5-exo ring closure of β-aminoalkyl radicals

✍ M.-P. Bertrand; S. Gastaldi; R. Nouguier 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 658 KB

Two methodologies, likely to enhance the diastereoselectivity of sultonyl radical mediated cyclization of dienes 8 and 11, were investigated. Quaternization provided the expected result whatever the nature of the radical acceptingdouble bond, so did complexation of 11 with BF 3 or AIMe 3. A more str