ChemInform Abstract: Indole as Neutral Leaving Group in Silver Nitrate Induced Cyclization Reactions of N-{2-[Alkynyl(hetero)aryl]methylene}indolin-1-amines for the Synthesis of Annulated Pyridine Derivatives.

Indole as Neutral Leaving Group in Silve

Indole as Neutral Leaving Group in Silver Nitrate Induced Cyclization Reactions of N-{2-[Alkynyl(hetero)aryl]methylene}indolin-1-amines for the Synthesis of Annulated Pyridine Derivatives

✍ Nugzar Ghavtadze; Roland Fröhlich; Ernst-Ulrich Würthwein 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB

## Abstract __N__‐{2‐[Alkynyl(hetero)aryl]methylene}indolin‐1‐amines **3** undergo, upon treatment with silver nitrate in chloroform at 60 °C, electrophilic cyclization reactions to afford annulated pyridine derivatives **4**. Mechanistically, the silver(I)‐assisted 6‐__endo__‐__dig__ ring‐closure