ChemInform Abstract: Imidazole Transfer from 1,1′-Carbonyldiimidazole and 1,1′-(Thiocarbonyl)diimidazole to Alcohols. A New Protocol for the Conversion of Alcohols to Alkylheterocycles.

✍ Scribed by M. J. TOTLEBEN; J. P. FREEMAN; J. SZMUSZKOVICZ

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199811135

✦ Synopsis

Imidazole Transfer from 1,1'-Carbonyldiimidazole and 1,1'-(Thiocarbonyl)diimidazole to Alcohols. A New Protocol for the Conversion of Alcohols to Alkylheterocycles.

-With activated alcohols the imidazole transfer proceeds in moderate to excellent yields and with retention of stereochemistry. Unactivated alcohols generally give carbonylimidazole esters like (IV). 1,1'-Carbonyldi-1,2,4-triazole (V) is found to react similarly. -(TOTLEBEN, M.