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ChemInform Abstract: How Druggable Is Protein Kinase CK2?

✍ Scribed by Giorgio Cozza; Andrea Bortolato; Stefano Moro

Publisher
John Wiley and Sons
Year
2010
Weight
15 KB
Volume
41
Category
Article
ISSN
0931-7597

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How druggable is protein kinase CK2?
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CK2 is a pleiotropic, ubiquitous, and constitutively active protein kinase (PK), with both cytosolic and nuclear localization in most mammalian cells. The holoenzyme is generally composed of two catalytic (alpha and/or alpha') and two regulatory (beta) subunits, but the free alpha/alpha' subunits ar

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