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ChemInform Abstract: How Does Organic Structure Determine Organic Reactivity? Nucleophilic Substitution and Alkene-Forming Elimination Reactions of α- Carbonyl and α-Thiocarbonyl Substituted Benzyl Derivatives.

✍ Scribed by J. P. RICHARD; S.-S. LIN; J. M. BUCCIGROSS; T. L. AMYES


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


How Does Organic Structure Determine Organic Reactivity? Nucleophilic Substitution and Alkene-Forming Elimination Reactions of α-Carbonyl and α-Thiocarbonyl Substituted Benzyl Derivatives.

-Experimental and computational studies are reported in order to characterize the effect of α-(N,N-dimethylcarbamoyl) and α-(N,N-dimethylthiocarbamoyl) substituents on the rate constants of solvolysis and deprotonation. The results are discussed in terms of the relative thermodynamic stabilities of the neutral products. -(RICHARD,