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ChemInform Abstract: Highly Selective Glycosylated Prodrugs of Cytostatic CC-1065 Analogues for Antibody-Directed Enzyme Tumor Therapy.

✍ Scribed by Lutz F. Tietze; Tobias Herzig; Fecher Anja Fecher Anja; Frank Haunert; Ingrid Schuberth

Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
33
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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Highly Selective Glycosylated Prodrugs o
Highly Selective Glycosylated Prodrugs of Cytostatic CC-1065 Analogues for Antibody-Directed Enzyme Tumor Therapy
✍ Lutz F. Tietze; Tobias Herzig; Anja Fecher; Frank Haunert; Ingrid Schuberth 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 1 views

Novel prodrugs of the cytotoxic antibiotic CC-1065 for an antibody-directed enzyme prodrug therapy (ADEPT) were prepared that show an excellent selectivity with a high toxicity of the corresponding drug. In particular, the seco-CBI analogue of CC-1065, 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]