ChemInform Abstract: Highly Enantioselective Henry Reactions in Water Catalyzed by a Copper Tertiary Amine Complex and Applied in the Synthesis of (S)-N-trans-Feruloyl Octopamine.

✍ Scribed by Guoyin Lai; Fengfeng Guo; Yueqin Zheng; Yang Fang; Haigang Song; Kun Xu; Sujing Wang; Zhenggen Zha; Zhiyong Wang

• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 55 KB
• Volume: 42
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201121072

✦ Synopsis

Abstract

Asymmetric Henry reaction of nitromethane with a diversity of aromatic or aliphatic aldehydes proceeds efficiently in water under phase‐transfer catalysis conditions with a Cu(II)—prolinol‐derived tridentate ligand complex.