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ChemInform Abstract: Highly Diastereoselective Synthesis of Substituted Pyrrolidines Using a Sequence of Azomethine Ylide Cycloaddition and Nucleophilic Cyclization.

✍ Scribed by Guillaume Belanger; Veronique Darsigny; Michael Dore; Francois Levesque

Publisher
John Wiley and Sons
Year
2010
Weight
36 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

This new method allows formation of a number of indolizidine derivatives with high diastereoselectivity.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Application of meso
ChemInform Abstract: Application of meso-Hydrobenzoin-Derived Chiral Auxiliaries for the Stereoselective Synthesis of Highly Substituted Pyrrolidines by 1,3-Dipolar Cycloaddition of Azomethine Ylides.
✍ Katharina Bica; Peter Gaertner πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 32 KB πŸ‘ 1 views

## Abstract Acrylic ester derivatives (I) possessing meso‐hydrobenzoin derived chiral auxiliaries undergo cycloaddition with the azomethine (II) to give the highly substituted pyrrolidines (III) with up to 87% e.e.