ChemInform Abstract: Highly Diastereoselective Aza-Aldol Reactions of a Chiral Ni(II) Complex of Glycine with Imines. An Efficient Asymmetric Approach to 3- Perfluoroalkyl-2,3-diamino Acids.

✍ Scribed by V. A. SOLOSHONOK; D. V. AVILOV; V. P. KUKHAR; L. VAN MEERVELT; N. MISCHENKO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199740103

✦ Synopsis

1997 aminocarboxylic acids

aminocarboxylic acids (hydrazinocarboxylic acids) and esters (acyclic compounds) P 0270

40 -103

Highly Diastereoselective Aza-Aldol Reactions of a Chiral Ni(II) Complex of Glycine with Imines. An Efficient Asymmetric Approach to 3-Perfluoroalkyl-2,3-diamino Acids.

-A highly diastereoselective LiCl and base-promoted aldol-type reaction of the imine (I) and the enantiopure Ni(II) complex (II) provides an efficient access to the hitherto unknown stereochemically defined acid (IV). -(SOLOSHONOK, V. A.; AVILOV, D.