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ChemInform Abstract: Highly Diastereo- and Enantioselective Synthesis of Protected anti-1,3-Diols.

โœ Scribed by Dieter Enders; Thomas Hundertmark; Cornelia Lampe; Udo Jegelka; Ilse Scharfbillig


Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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Highly Diastereo- and Enantioselective S
โœ Dieter Enders; Thomas Hundertmark; Cornelia Lampe; Udo Jegelka; Ilse Scharfbilli ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 229 KB ๐Ÿ‘ 2 views

An efficient asymmetric synthesis of protected anti-1,3-diols by reduction of the ketones 2 and a variant of the Barton-McCombie deoxygenation. The new method allows the 5 (de ี† 98%, ee = 92-98%) from 2,2-dimethyl-1,3-dioxan-5one SAMP hydrazone 1 is described. The key steps are the synthesis of acet