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ChemInform Abstract: Heterocyclization of 4-Trifluoroacetyl-2,3-dihydropyrroles with Hydrazines and Amidines: A New Access to Trifluoromethylated Pyrazoles and Pyrimidines Bearing a β-Aminoethyl Side Chain.

✍ Scribed by Masami Kawase; Michitaka Hirabayashi; Setsuo Saito; Katsumi Yamamoto


Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis


Heterocyclization of 4-Trifluoroacetyl-2,3-dihydropyrroles with Hydrazines and Amidines: A New Access to Trifluoromethylated Pyrazoles and Pyrimidines Bearing a β-Aminoethyl Side Chain. -Condensation of dihydropyrrole (I) with hydrazines opens a new access to trifluoromethylated pyrazoles (III)/(IV). Similarly, condensation with amidines gives the corresponding pyrimidines (VI). -(KAWASE, MASAMI;