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ChemInform Abstract: Glycosylphosphatidylinositols Are Potential Targets for the Development of Novel Inhibitors for Aerolysin-Type of Pore-Forming Bacterial Toxins

✍ Scribed by Qiuye Wu; Zhongwu Guo

Publisher: John Wiley and Sons
Year: 2010
Weight: 15 KB
Volume: 41
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201024225

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✦ Synopsis

Abstract

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Glycosylphosphatidylinositols are potent

Glycosylphosphatidylinositols are potential targets for the development of novel inhibitors for aerolysin-type of pore-forming bacterial toxins

✍ Qiuye Wu; Zhongwu Guo 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB

## Abstract Many bacteria produce toxins that cause damage through the formation of pores in the host cell membrane. Some of these toxins, such as aerolysin, use glycosylphosphatidylinositols (GPIs) as their binding receptors to assist the pore formation on the host cell surface and the subsequent