ChemInform Abstract: Glycosylation via Locked Anomeric Configuration: Stereospecific Synthesis of Oligosaccharides Containing the β-D-Mannopyranosyl and β-L-Rhamnopyranosyl Linkage.

✍ Scribed by G. HODOSI; P. KOVAC

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199844200

✦ Synopsis

Glycosylation via Locked Anomeric Configuration: Stereospecific Synthesis of Oligosaccharides Containing the β-D-Mannopyranosyl and β-L-Rhamnopyranosyl Linkage. -cis-1,2-Stannylene acetals derived from D-mannose and L-rhamnose are capable of displacing the triflyl leaving groups in carbohydrates to give cis-1,2-linked oligosaccharides [cf. (III), (VI)] in a highly stereospecific fashion. Combination of this glycosylation via locked anomeric configuration with conventional glycosylation techniques providing access to more complex oligosaccharides is demonstrated. -(HODOSI,