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ChemInform Abstract: Glycine Amides as PPARα Agonists.

✍ Scribed by Klaus Urbahns; Michael Woltering; Susanne Nikolic; Josef Pernerstorfer; Hilmar Bischoff; Elke Dittrich-Wengenroth; Klemens Lustig

Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
41
Category
Article
ISSN
0931-7597

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Bioisosteric replacement of the rigid oxazole ring of a previously reported PPARα/γ dual agonist with a flexible lipophilic tail leads to a series of oxime containing benzyl dioxanecarboxylic acid derivatives. Compounds (I) show high selectivity towards PPARα over PPARγ in vitro. Furthermore, the hi