ChemInform Abstract: Formation of Aziridine-2-amides Through 5-Halo-6-methylperhydropyrimidin-4-ones. A Route to Enantiopure L- and D-Threonine and allo-Threonine.

✍ Scribed by G. CARDILLO; L. GENTILUCCI; A. TOLOMELLI; C. TOMASINI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 38 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199838231

✦ Synopsis

Formation

of Aziridine-2-amides Through 5-Halo-6methylperhydropyrimidin-4-ones.

A Route to Enantiopure Land D-Threonine and allo-Threonine.

-Hydrolysis of 5-halo-6methylperhydropyrimidinones leads to carboxyaziridines which can easily be transformed into enantiomerically pure threonines and allo-threonines.