ChemInform Abstract: Formal Desymmetrization by a “Mitsunobu Trick” — Enantiomerically Pure cis-3,4-Dihydroxypyrroline N-Oxides for the Enantiodivergent Synthesis of Trihydroxyindolizidines.

Formal Desymmetrization by a “Mitsunobu

Formal Desymmetrization by a “Mitsunobu Trick” − Enantiomerically Pure cis-3,4-Dihydroxypyrroline N-Oxides for the Enantiodivergent Synthesis of Trihydroxyindolizidines

✍ Stefano Cicchi; José Nunes Jr.; Andrea Goti; Alberto Brandi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB

A protocol is presented for a completely enantioselective for-sunobu trick"). Its application to the unprecedented synthesis of enantiopure cis-3,4-dihydroxypyrroline N-oxides, em-mal desymmetrization of C s -symmetric diols by monoprotection of the corresponding enantiopure C 2 diols, followed by p