ChemInform Abstract: Follow the Protons: A Low-Barrier Hydrogen Bond Unifies the Mechanisms of the Aspartic Proteases

Dimerization and solvent-assisted proton

Dimerization and solvent-assisted proton dislocation in the low-barrier hydrogen bond of a Mannich base: a low-temperature NMR study

✍ Maria Rospenk; Lucjan Sobczyk; Parwin Schah-Mohammedi; Hans-Heinrich Limbach; Ni 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB

Using low-temperature UV, 1 H and 15 N NMR spectroscopy, we studied the easily polarizable bond of the labeled Mannich base[ 15 N] 2-(N,Ndiethylaminomethyl)-3,4,6-trichlorophenol (Cl 3 MB) dissolved in dichloromethane and in a 2 : 1 mixture of CDF 3 and CDClF 2 . Whereas at high temperature the mol