Fluorine-Sacrificial Cyclizations as an
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Jean-NoΓ«l Volle; Manfred Schlosser
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Article
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2000
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John Wiley and Sons
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English
β 263 KB
Methyl 3-methoxy-2-trifluoromethylacrylate 1, readily prepared by Wittig reaction from methyl 3,3,3-trifluoropyruvate, has been treated with a number of aryl-(or hetaryl-) hydrazines. Under mild base-catalysis, the resulting 3-hydrazinoacrylates 6 undergo consecutive hydrogen fluoride elimination an