ChemInform Abstract: First General Method for Direct Formylation of Kinetically-Generated Ketone Enolates.

✍ Scribed by Gregory H. Zayia

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199952072

✦ Synopsis

First General Method for Direct Formylation of Kinetically-Generated Ketone Enolates.

-Ketone enolates react rapidly with 2,2,2-trifluoroethyl formate (II) to yield α-formyl ketones. In addition, in appropriate cases such as (VIII), a complete reversal of regiochemistry compared to the classical Claisen reaction is observed. -(ZAYIA,