First Efficient Syntheses of 1-, 4-, and
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Michael Sefkow; Alexandra Kelling; Uwe Schilde
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Article
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2001
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John Wiley and Sons
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English
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Efficient synthesis of 1-, 4-, and 5-caffeoylquinic acid was achieved in three or four steps with suitably protected quinic acid precursors, in overall yields of 41%, 36%, and 60% [from quinic acid (1)]. 1-Caffeoylquinic acid was prepared by esterification of acetone quinide 7 with caffeoyl chloride