ChemInform Abstract: First Efficient Preparation of Enantiopure 10-Bromofenchone: The Key Intermediate to C10-Substituted Fenchone-Derived Chiral Sources.

First efficient preparation of enantiopu

First efficient preparation of enantiopure 10-bromofenchone: the key intermediate to C10-substituted fenchone-derived chiral sources

✍ Antonio Garcı́a Martı́nez; Enrique Teso Vilar; Amelia Garcı́a Fraile; Santiago d 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 79 KB

The first efficient preparation of enantiopure 10-bromofenchone from commercially available fenchone is described. The synthetic procedure is based on two consecutive Wagner-Meerwein rearrangements of the fenchone skeleton, taking place straightforwardly in only three individual steps with a high ov