ChemInform Abstract: First Diastereoselective Asymmetric Carbometallation of Chiral Vinyl Metals.

✍ Scribed by D. BRASSEUR; H. REZAEI; A. FUXA; A. ALEXAKIS; P. MANGENEY; I. MAREK; J. F. NORMANT

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199839021

✦ Synopsis

First Diastereoselective Asymmetric Carbometallation of Chiral Vinyl Metals.

-Reaction of (Z) metalated allyl amines such as (I) bearing a chiral aromatic amine moiety with substituted allylic zinc reagents is face-selective providing β-methylated amines (III) with good diastereoselectivity.