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ChemInform Abstract: Facile Transformation of Biginelli Pyrimidin-2(1H)-ones to Pyrimidines. In vitro Evaluation as Inhibitors of Mycobacterium tuberculosis and Modulators of Cytostatic Activity.

✍ Scribed by Kamaljit Singh; Kawaljit Singh; Baojie Wan; Scott Franzblau; Kelly Chibale; Jan Balzarini

Publisher: John Wiley and Sons
Year: 2011
Weight: 37 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201139149

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✦ Synopsis

Abstract

While none of the compounds tested for inhibition of M.tuberculosis displays useful activity, the nature of the C‐2 substituent is found to modulate the cytostatic activity in cell culture.

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