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ChemInform Abstract: Facile Synthesis of β-Hydroxy-δ-valerolactone via the Ring Opening Reaction of β-Trichloromethyl-β-propiolactone with Ester Enolates.

✍ Scribed by M. SHIMIZU; K. ISHII; T. FUJISAWA


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
28
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Facile Synthesis of
✍ T. FUJISAWA; T. ITO; K. FUJIMOTO; M. SHIMIZU; H. WYNBERG; E. G. J. STARING 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 33 KB

Facile Synthesis of (S)-β-Hydroxy-β-trichloromethylated Aromatic Ketones by the Regioselective Ring Cleavage of Chiral β-Trichloromethyl-β-propiolactone under the Friedel-Crafts Conditions. -The enantiopure lactone (I) undergoes regioselective Friedel-Crafts acylation with a variety of arenes to giv