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ChemInform Abstract: Facile Synthesis of Stereoisomers of the Non-Secosteroidal Ligand LG190178 and Their Evaluation Using the Mutant Vitamin D Receptor.

✍ Scribed by Yosuke Demizu; Aki Nakatsu; Yukiko Sato; Shinobu Honzawa; Atsushi Yamashita; Takayuki Sugiura; Atsushi Kittaka; Shigeaki Kato; Haruhiro Okuda; Masaaki Kurihara

Publisher: John Wiley and Sons
Year: 2011
Weight: 30 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201127091

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✦ Synopsis

Facile Synthesis of Stereoisomers of the Non-Secosteroidal Ligand LG190178 and Their Evaluation Using the Mutant Vitamin D Receptor. -All four diastereomers of the non-secosteroidal ligand LG190178 are prepared by asymmetric reduction of bisphenol derivative (I) with chiral oxazaborolidine reagents followed by treatment with the corresponding glycidol derivatives, e.g. (III). -(DEMIZU*, Y.; NAKATSU,

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