ChemInform Abstract: Facile and Effective Synthesis of Spirocycloalkanones.

✍ Scribed by Grigoris Zoidis; Nicolas Kolocouris

• Book ID: 102072059
• Publisher: John Wiley and Sons
• Year: 2012
• Weight: 33 KB
• Volume: 43
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201205052

✦ Synopsis

Abstract

A facile and experimentally convenient protocol for the construction of spirocarbocyclic adamantane derivatives (VIII) is developed involving intramolecular Thorpe—Ziegler cyclization of dinitriles (VI) as the key step.