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ChemInform Abstract: Exploring the Role of Chirality in Nucleic Acid Recognition

✍ Scribed by Daniele D'Alonzo; Annalisa Guaragna; Giovanni Palumbo


Publisher
John Wiley and Sons
Year
2011
Weight
18 KB
Volume
42
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Peptide nucleic acids are DNA mimics able to form duplexes with complementary DNA or RNA strands of remarkable affinity and selectivity. Oligopyrimidine PNA can displace one strand of dsDNA by forming PNA(2):DNA triplexes of very high stability. Many PNA analogs have been described in recent years,