ChemInform Abstract: Et2AlCl-Promoted Coupling Reactions of 4-Hydroxy-2-pyrone or 4-Hydroxycoumarin with Aldehydes: Synthesis of Methylenebis(4-hydroxy-2-pyrone) or Methylenebis(4-hydroxycoumarin) Derivatives.

✍ Scribed by Hisahiro Hagiwara; Shigeki Miya; Toshio Suzuki; Masayoshi Ando; Isao Yamamoto; Michiharu Kato

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199929138

✦ Synopsis

Et 2 AlCl-Promoted Coupling Reactions of 4-Hydroxy-2-pyrone or 4-Hydroxycoumarin with Aldehydes: Synthesis of Methylenebis(4hydroxy-2-pyrone) or Methylenebis(4-hydroxycoumarin) Derivatives. -Condensation of pyrone derivatives (I) with aldehydes (II) in the presence of Et 2 AlCl easily affords the methylene-bridged bis-derivatives (III). These products are of interest as pharmaceutical agents. -(HAGIWARA, HISAHIRO;