ChemInform Abstract: Enzymes in Organic Synthesis. Part 26. Synthesis of Enantiomerically Enriched 2,3- and 3,4-Dimethylpentan-5-olides by Lipase-Catalyzed Regio- and Enantioselective Alcoholysis of cis- and trans-2,3- Dimethylpentanedioic Anhydrides.

Enzymes in Organic Synthesis, 26. Synthe

Enzymes in Organic Synthesis, 26. Synthesis of Enantiomerically Enriched 2,3- and 3,4-Dimethylpentan-5-olides by Lipase-Catalyzed Regio- and Enantioselective Alcoholysis of cis- and trans-2,3-Dimethylpentanedioic Anhydrides

✍ Ozegowski, Rüdiger ;Kunath, Annamarie ;Schick, Hans 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 680 KB

## Abstract The enzyme‐catalyzed regio‐ and enantioselective alcoholysis of racemic __cis__‐ and __trans__‐2,3‐dimethylpentanedioc anhydride in the presence of Novozym 435 from __Candida antarctica__ afforded two of the eight possible monoesters with an enantiomeric excess higher than 90%. Regiosel