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ChemInform Abstract: Enzymatic Synthesis of the Glycosides of Calystegines B1 and B2 and Their Glycosidase Inhibitory Activities.

✍ Scribed by N. ASANO; A. KATO; H. KIZU; K. MATSUI; R. C. GRIFFITHS; M. G. JONES; A. A. WATSON; R. J. NASH

Publisher: John Wiley and Sons
Year: 2010
Weight: 41 KB
Volume: 29
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199812182

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✦ Synopsis

Enzymatic Synthesis of the Glycosides of Calystegines B 1 and B 2 and Their Glycosidase Inhibitory Activities.

-Although the βtransglucosylation with cellobiose (II) gives the corresponding β-D-glucosides of both calystegine B 1 (I) and calystegine B 2 (IV), the β-transgalactosylation with lactose (VIII) is only successful for calystegine B 2 and the α-transglucosylation with mannose (VI) only for calystegine B 1 . Glycosylation markedly decreases or abolishes the inhibitory potential of calystegines against β-glucosidase, α-or β-galactosidase. (IX) however retains more or less the potency of calystegine B 2 against trehalase and (III) is a noncompetitive inhibitor of rice α-glucosidase.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v