✦ LIBER ✦
ChemInform Abstract: Enzymatic Kinetic Resolution of 5-Hydroxy-4-oxa-endo-tricyclo(5.2.1.02, 6)dec-8-en-3-ones: A Useful Approach to D-Ring Synthons for Strigol Analogues with Remarkable Stereoselectivity.
✍ Scribed by J. W. J. F. THURING; G. H. L. NEFKENS; M. A. WEGMAN; A. J. H. KLUNDER; B. ZWANENBURG
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Enzymatic
Kinetic Resolution of 5-Hydroxy-4-oxa-endotricyclo(5.2.1.02, 6)dec-8-en-3-ones: A Useful Approach to D-Ring Synthons for Strigol Analogues with Remarkable Stereoselectivity.
-Racemic tricyclic hydroxy lactones (I) and (V) are resolved employing a lipase-catalyzed acetylation reaction. The kinetic resolution is accompanied by a remarkable epimerization at C-5, through which it is possible to achieve a highly efficient asymmetric synthesis of furanone (VIII). -(THURING,