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ChemInform Abstract: Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identification as Nitric Oxide (Nobel Lecture)

โœ Scribed by Robert F. Furchgott

Publisher
John Wiley and Sons
Year
2010
Weight
26 KB
Volume
30
Category
Article
ISSN
0931-7597

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Endothelium-Derived Relaxing Factor: Dis
Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identifcation as Nitric Oxide (Nobel Lecture)
โœ Robert F. Furchgott ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 188 KB

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle is clearly shown with organ-chamber experiments. Two preparations, a transverse ring and a helical strip from the same rabbit thoracic aorta, were incubated in an organ bath and contracted with noradrenaline (NE).