ChemInform Abstract: Enantioselective Synthesis of the Four Isomers of the Biologically Active Metabolite of the 2-Arylpropanoic Acid NSAID, Ximoprofen, and Assessment of Their Inhibitory Activity on Human Platelet Cyclooxygenase in vitro.

Enantioselective synthesis of the four i

Enantioselective synthesis of the four isomers of the biologically active metabolite of the 2-arylpropanoic acid NSAID, ximoprofen, and assessment of their inhibitory activity on human platelet cyclo-oxygenase in vitro

✍ David P.G. Hamon; Peter J. Hayball; Ralph A. Massy-Westropp; Josephine L. Newton 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 450 KB

The four stereoisomers of the parent keto acid of the oximino drug ximoprofen have been prepared in high enantiomeric purity. The stereochemistry in the propionic acid chain was established by the combination of Sharpless epoxidation followed by stereoselective hydrogenolysis of the benzylic carbon-