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ChemInform Abstract: Enantioselective Synthesis of SSR 241586 by Using an Organo-Catalyzed Henry Reaction.

✍ Scribed by Anne Cochi; Thomas-Xavier Metro; Domingo Gomez Pardo; Janine Cossy

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
41
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

Addition of nitromethane to the keto ester (I) in the presence of QUI and subsequent cyclization of the amide (IV) allows formation of the biologically active title compound (VI) with high enantioselectivity.

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