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ChemInform Abstract: Enantioselective Synthesis of Protected α-Hydroxy Aldehydes (IV), (VII) via Alkylation of Metalated Chiral Hydrazones.

✍ Scribed by D. ENDERS; U. REINHOLD


Book ID
112021091
Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
26
Category
Article
ISSN
0931-7597

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Enantioselective synthesis of protected
✍ Dieter Enders; Vidya Bhushan 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 282 KB

a-Benzyloxy aldehydes and a-acetoxy ketones 4 of high enantiomeric purity are prepared in good overall yields via oxaziridine mediated hydroxylation of chiral hydrazone azaenolates. As auxiliaries novel proline derived hydrazine reagents 5 are used. The importance of a-hydroxy carbonyl compounds as