ChemInform Abstract: Enantioselective Syntheses of 2,5-Disubstituted Pyrrolidines Based on Iridium-Catalyzed Allylic Aminations — Total Syntheses of Alkaloids from Amphibian Skins.

Enantioselective Syntheses of 2,5-Disubs

Enantioselective Syntheses of 2,5-Disubstituted Pyrrolidines Based on Iridium-Catalyzed Allylic Aminations—Total Syntheses of Alkaloids from Amphibian Skins

✍ Martin Gärtner; Dr. Robert Weihofen; Prof. Dr. Günter Helmchen 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 512 KB

## Abstract A broadly applicable route to __trans__‐2,5‐disubstituted pyrrolidines has been developed. Key steps are an asymmetric iridium‐catalyzed allylic amination, a Suzuki–Miyaura coupling, and an intramolecular aza‐Michael addition. Enantiomeric excesses in the range of 93–99 % __ee__ have be